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Of note, Insr expression was found upregulated in mouse lungs with compromised IGF1R signaling [21,22,23, 37], and IGF1 expression by the TME was reported to have a supportive role in tumor initiation and progression [16, 24]

PubMed Hutter-Paier, B., Grygar, E., Windisch, M., & Skofitsch, G

On one hand, nutritional immunity serves as a mechanism employed by immune cells to reduce the availability of zinc in the phagosome or cytoplasm, limiting its access and creating a phenomenon that restricts essential transition metal ions, including iron, zinc, selenium, and manganese, at the host-pathogen interface